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Masahiro Iwata Selected Research

3- (4- (3- chlorophenyl)- 1- ethyl- 7- methyl- 2- oxo- 1,2- dihydro- 1,8- naphthyridin- 3- yl)propanoic acid

1/2012Therapeutic potential of ASP3258, a selective phosphodiesterase 4 inhibitor, on chronic eosinophilic airway inflammation.
1/2012Anti-neutrophilic inflammatory activity of ASP3258, a novel phosphodiesterase type 4 inhibitor.
6/2011ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity.
5/2011Disease-modifying effect of ASP3258, a novel phosphodiesterase type 4 inhibitor, on subchronic cigarette smoke exposure-induced lung injury in guinea pigs.

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Masahiro Iwata Research Topics

Disease

6Inflammation (Inflammations)
09/2020 - 05/2008
3Pleurisy (Pleuritis)
09/2020 - 08/2002
3Cerebral Infarction
12/2009 - 06/2009
3Thyroid Neoplasms (Thyroid Cancer)
04/2004 - 06/2002
2Pain (Aches)
12/2019 - 05/2015
2Vomiting
01/2012 - 06/2011
2Chronic Obstructive Pulmonary Disease (COPD)
01/2012 - 05/2011
2Infarction (Infarctions)
12/2009 - 06/2009
2Neoplasm Metastasis (Metastasis)
04/2004 - 09/2002
2Thyroiditis
06/2003 - 06/2002
2Hypothyroidism
06/2003 - 06/2002
1Demyelinating Diseases (Demyelinating Disease)
09/2020
1Peripheral Nerve Injuries
09/2020
1Wounds and Injuries (Trauma)
01/2019
1Muscular Atrophy (Muscle Atrophy)
03/2017
1Eosinophilia
01/2012
1Pneumonia (Pneumonitis)
01/2012
1Vascular System Injuries
01/2012
1Asthma (Bronchial Asthma)
01/2012
1Lung Injury
05/2011
1Edema (Dropsy)
01/2010
1Necrosis
01/2010
1Ischemia
12/2009
1Ischemic Stroke
12/2009
1Brain Edema (Cerebral Edema)
12/2009
1Atherosclerosis
05/2008
1Sepsis (Septicemia)
01/2007
1Erythema
02/2006
1Abdominal Pain (Pain, Abdominal)
08/2004
1Carcinoma (Carcinomatosis)
04/2004
1Papillary Carcinoma
07/2002
1Neoplasms (Cancer)
07/2002
1Goiter
06/2002
1Atrophy
06/2002
1Graves Disease (Basedow Disease)
06/2002
1Suppurative Thyroiditis
06/2002
1Adenoma (Adenomas)
06/2002

Drug/Important Bio-Agent (IBA)

43- (4- (3- chlorophenyl)- 1- ethyl- 7- methyl- 2- oxo- 1,2- dihydro- 1,8- naphthyridin- 3- yl)propanoic acidIBA
01/2012 - 05/2011
4HMGB1 Protein (HMG1)IBA
01/2010 - 01/2007
3CarrageenanIBA
09/2020 - 08/2002
3RoflumilastIBA
01/2012 - 06/2011
3Phosphodiesterase 4 InhibitorsIBA
01/2012 - 05/2011
2EnzymesIBA
09/2020 - 01/2010
2Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2020 - 01/2010
2Proteins (Proteins, Gene)FDA Link
03/2017 - 12/2009
2CilomilastIBA
01/2012 - 06/2011
2EdaravoneIBA
12/2009 - 06/2009
2Free Radical ScavengersIBA
12/2009 - 06/2009
2IodineIBA
04/2004 - 06/2003
1Activating Transcription Factor 3IBA
09/2020
1Heme Oxygenase-1IBA
09/2020
1Carbon MonoxideIBA
09/2020
1Dexamethasone (Maxidex)FDA LinkGeneric
03/2017
1GlucocorticoidsIBA
03/2017
1LipopolysaccharidesIBA
01/2012
1OvalbuminIBA
01/2012
1Dihydrotachysterol (AT 10)IBA
01/2012
1Prednisolone (Predate)FDA LinkGeneric
01/2012
1Adrenergic Receptors (Adrenergic Receptor)IBA
01/2012
1EmeticsIBA
06/2011
1SmokeIBA
05/2011
1NOC 18IBA
01/2010
1Nitric Oxide Synthase (NO Synthase)IBA
01/2010
1DNA-Binding Proteins (DNA Binding Protein)IBA
01/2010
1AntioxidantsIBA
01/2010
1Arginine (L-Arginine)FDA Link
01/2010
1Minocycline (Cyclops)FDA LinkGeneric
07/2009
1Biomarkers (Surrogate Marker)IBA
05/2008
1IgG Receptors (Fc gamma RI)IBA
05/2008
1C-Reactive ProteinIBA
05/2008
1EndotoxinsIBA
01/2007
1Adrenal Cortex Hormones (Corticosteroids)IBA
02/2006
1RadiopharmaceuticalsIBA
04/2004
1Fluorine-18IBA
04/2004
1Technetium Tc 99m Sestamibi (Cardiolite)FDA LinkGeneric
04/2004
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
04/2004
1Radioisotopes (Radionuclides)IBA
09/2002
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2002
1Thyrotropin Receptors (Thyrotropin Receptor)IBA
06/2002
1AntibodiesIBA
06/2002

Therapy/Procedure

3Muscle Stretching Exercises (Stretching, Static)
12/2019 - 05/2015
3Therapeutics
08/2004 - 09/2002
1Anesthesia
06/2011
1Intravenous Administration
06/2009
1Blood Component Removal (Apheresis)
08/2004
1Thyroidectomy
07/2002